Klf5 phosphorylation
WebJul 23, 2009 · To understand whether the change in KLF5 phosphorylation is responsible for the increased interaction between KLF5 and c-Jun, we detected the levels of phospho-KLF5 in VSMCs treated with Ang II. As shown in Fig. 3 A, Ang II stimulation rapidly induced phosphorylation of KLF5 within 0.5 h, and KLF5 phosphorylation reached the maximum at … WebOct 11, 2024 · KLF5/BTEB2 is an essential transcription factor that causes not only smooth muscle phenotypic modulation but also cardiac hypertrophy and fibrosis; KLF5 has a role …
Klf5 phosphorylation
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WebApr 17, 2009 · Protein phosphorylation has been an important mechanism by which a transcription activator recruits coactivators, such as phosphorylation of cAMP response element-binding protein (CREB) at Ser133 leading to the recruitment of CREB-binding protein (CBP) [23], phosphorylation of KLF5 at the CBP interaction region enhancing its … WebDownload scientific diagram Role of AMPK/mTOR pathway in morusin-induced autophagy in non-small cell lung cancer cells. Cells were treated with morusin (20 μM) at various time periods. (A) The ...
WebJul 2, 2007 · KLF5 loss specifically resulted in reduced Bad phosphorylation at both ser112 and ser136 residues. Densitometric analysis confirmed that reduced Bad phosphorylation was significant across... WebNov 16, 2012 · Abstract 2313. Krüppel-like factor 5 (KLF5) is a member of a highly conserved group of transcription factors (the KLF family) that have regulatory roles in …
Web6.1 Phosphorylation. KLF5 has been shown to be phosphorylated by protein kinase C (PKC) at S153, which upregulates its transactivation activities by enhancing the interaction … WebApr 15, 2003 · GST–KLF5 fusion protein was phosphorylated by 125 mM ATP as described above. After the reactions, the bound and phosphorylated GST–KLF5 was washed with GST pull‐down buffer (20 mM HEPES, pH 7.5, 0.1 mM EDTA, 75 mM KCl, 2.5 mM MgCl 2, 0.05% NP‐40) three times.
WebKrüppel-like factor 5 (KLF5) is an oncogenic factor that is highly expressed in basal-like breast cancer (BLBC) and promotes cell proliferation, survival, migration, stemness, and tumor growth; however, its posttranslational modifications are poorly defined.
WebMay 10, 2024 · PRMT5 and KLF5 protein levels were positively correlated in clinical BLBCs. Taken together, PRMT5 methylates KLF5 to prevent its phosphorylation, ubiquitination, and degradation, and thus... do goats eat johnson grassWebMar 8, 2011 · Phosphorylation of HDAC2 switches its interaction preference from RAR to Klf5, and thus promotes Klf5 deacetylation. Deacetylated Klf5 then dissociates from the p21 promoter, and the... failed to launch game error code 740WebMar 30, 2024 · EMT played an important role in platinum resistance, while oxidative phosphorylation is the opposite. There was a small subset of cells in platinum-sensitive samples which had transcriptomic characteristics similar to platinum-resistant cells, suggesting that the progression of platinum resistance in ovarian cancer is inevitable. do goats eat grass rootsWebApr 14, 2024 · Enhancer RNAs (eRNAs) are non-coding RNAs (ncRNAs) transcribed in enhancer regions. They play an important role in transcriptional regulation, mainly during cellular differentiation. eRNAs are tightly tissue- and cell-type specific and are induced by specific stimuli, activating promoters of target genes in turn. eRNAs usually have a very … failed to launch javascriptWebApr 4, 2024 · correlation between the KLF5 and ZEB1 transcription levels in the pancreatic tumor tissues The present study has identified that KLF5, a target of miR-145-5p, is a key … failed to launch help windows 10WebMar 16, 2009 · To understand whether the change in KLF5 phosphorylation is responsible for Am80-induced suppression of interaction between KLF5 and RARα, we detected the levels of phospho-KLF5 in VSMCs treated with Am80. As shown in Fig. 3 A, Am80 stimulation rapidly induced dephosphorylation of KLF5 within 30 min. KLF5 … failed to launch hos switchWebApr 11, 2024 · SPI1, HIF1A, STAT1, KLF5, RUNX1, MBD1, SP1, and WT1 may be involved in the regulatory mechanisms of DN development. Our study may provide a potential biomarker or therapeutic locus for the study of DN. ... (Zhang et al., 2024c), STAT1 phosphorylation inhibited the M1 phenotypic transformation of macrophages and suppressed DN … do goats eat goat heads