Hth-01-015

Author: bfja

August undefined, 2024

WebHTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM). 体外活性. In HEK-293 cells express NUAK1 as well as NUAK2, HTH-01-015 suppresses NUAK1-mediated MYPT1 … WebThe inhibitors WZ4003 and HTH-01-015 belong to the first generation of NUAK inhibitors and can be considered relatively specific, as they inhibited the NUAKs without inhibiting …

NUAK1 governs centrosome replication in pancreatic cancer via …

WebHTH-01-015 是一种有效的选择性 NUAK1 抑制剂，比作用于NUAK2的选择性高100多倍。 Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations. WebHTH-01-015是一高效选择性NUAK1抑制剂，IC50值为100nM，对NUAK2无明显抑制（IC50>10uM）。. 注：本品仅可用于科研实验，严禁用于临床医疗及其他用途！. CAS … justfab by techstyle london

HTH-01-015 CAS#1613724-42-7 NUAK1 inhibitor MedKoo

Web1 sep. 2024 · The compounds WZ4003 and HTH-01-015 are known inhibitors of NUAK1, indicating that residues Gly64, Val69, Gly138, and Asp196 of NUAK1 may be important … http://www.bjbalb.com/html/Inhibitor-Activator/M01070.html WebHTH-01-015 is a highly specific inhibitor of NUAK1 with IC50 value of 100 nM 1. HTH-01-015 showed extreme selectivity. It only inhibited the NUAK1 (NUAK family SNF1-like … just fab coconut water cream

NUAK family, SNF1-like kinase, 2 NuaK subfamily IUPHAR Guide …

WebHTH-01-015 has an IC 50 of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase … WebHTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. Availability: In stock Free Overnight Delivery on orders over $500 Next day delivery by 10:00 a.m. Order now. Add to Cart Bulk Inquiry Price Match Add to Wishlist justfab free shipping promoWebHTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2. CAS No. 1613724-42-7 Selleck's HTH-01-015 has been cited by … just fab gifts discount code

"WebHTH-01-015 impaired the invasive potential of U2OS cells in a 3D cell invasion assay to the same extent as NUAK1 knockdown. HTH-01-015 will serve as useful chemical probes to … " - Hth-01-015

Hth-01-015

Calcium signalling links MYC to NUAK1 Oncogene - Nature

Web19 mrt. 2024 · In addition, we used a well-characterized NUAK1 inhibitor, HTH-01-015 (Banerjee et al., 2014a). Notably, potential off-target activities of BAY-880 greatly differed from those of HTH-01-015, arguing that joint targets of both inhibitors reflect on-target effects resulting from NUAK1 inhibition (Figure S4 B). WebHTH-01-015 is a specific NUAK1 inhibitor. The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by …

Did you know?

Webhth-01-015是一种高特异性和高选择性的nuak1抑制剂，ic50值为100 nm[1]。 hth-01-015只抑制nuak激酶家族中的nuak1亚型，而对其它被测试的139个激酶没有显著的抑制活性 … WebHTH-01-015 is a highly specific inhibitor of NUAK1 with IC50 value of 100 nM 1. HTH-01-015 showed extreme selectivity. It only inhibited the NUAK1 (NUAK family SNF1-like kinase-1) isoform of NUAK kinases and showed no significant inhibition of 139 other tested kinases. HTH-01-015 inhibited the phosphorylation of the NUAK1 substrate, MYPT1.

Web21 mrt. 2024 · Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. WebConsistent with PTEN-SSL status, inhibition of the NUAK1 protein kinase by the small molecule drug HTH-01-015 selectively impaired viability in multiple PTEN-deficient …

Web2 mei 2024 · AMPK-related protein kinase 5 (ARK5) is a serine/threonine kinase that has been identified as the fifth member of the AMP-activated protein kinase (AMPK) family ( 4 ). ARK5 serves a role in the metastasis and invasion of colorectal (CRC) cancer, pancreatic cancer (PC), gastric cancer, hepatic cancer and squamous cell carcinoma ( 5-8 ). WebHTH 01-015 is a potent and selective NUAK1 inhibitor (IC 50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. …

WebHTH-01-015 Synonym (s): 5,13-Dihydro-4,5,13-trimethyl-2- [ [1- (4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho [2,3-e]pyrimido [5,4-b] [1,4]diazepin-6-one Empirical Formula (Hill Notation): C26H28N8O CAS No.: 1613724-42-7 Molecular Weight: 468.55 Match Criteria: Keyword All Photos ( 1) DMA-135

WebHTH-01-015是一高效选. 择性NUAK1抑制剂，IC50值为100nM，对NUAK2无明显抑制（IC50>10uM）。. 收藏. 价格询价. 产地 USA. 货号 EHJ-EJJ01853. 品牌慧嘉生 … justfab.com bootsWeb中文名称：HTH-01-015. CAS号：1613724-42-7. 分子量：.00. 标准纯度：95+%. SMILES：CC1=C2C (=NC (=N1)NC3=CN (C4CCNCC4)N=C3)N (C)C5=C … justfab free shipping codeWebBarrier integrity B cell (activation) Cellular signalling Chemotaxis & migration Cytokine production & signalling Immune regulation Immune system development Inflammation T cell (activation) Tissue repair Cell Types B-cells Dendritic cells Granulocytes Innate lymphoid cells Macrophages/monocytes Mast cells Natural killer (NK) cells justfab monthly subscriptionWebHTH-01-015 is a highly selective protein kinase inhibitor, which mainly affects ARK5 by inhibiting the phosphorylation of myosin phosphatase target subunit 1 (MYPT1), a substrate of ARK5 (125). justfab kids customer serviceWeb8 apr. 2024 · However, even with long term administration of antiviral HTH-01-015 providers, the incidence of HZ raises after discontinuation of prophylaxis [4, 13]. Although necessary, there is not plenty of evidence to support a minimum interval between transplantation and … justfab phone number customer careWeb30 jul. 2024 · N-myristoyltransferase (NMT) inhibitors that were initially developed for treatment of parasitic protozoan infections, including sleeping sickness, malaria, and leismaniasis, have also shown great promise as treatment for oncological diseases. The successful transition of NMT inhibitors, which are currently at preclinical to early clinical … just fab hair and cosmeticsWeb28 mrt. 2024 · NUAK1 expression in PDAC cell lines varies over a broad range (Fig. S1B). We selected DAN-G and Mia PaCa-2 cells as representative of NUAK1 overexpression … justfab reviews for shoes